Uutta tutkimustietoa

2018

Korkka I, Viheriälä T, Juuti-Uusitalo K, Uusitalo-Järvinen H, Skottman H, Hyttinen J, Nymark S. Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2018 Nov 4. doi: 10.1002/sctm.18-0026.

Hongisto H, Vattulainen M, Ilmarinen T, Mikhailova A, Skottman H. Efficient and Scalable Directed Differentiation of Clinically Compatible Corneal Limbal Epithelial Stem Cells from Human Pluripotent Stem Cells. J Vis Exp. 2018 Oct 24;(140).

Kaur S, Abu-Shahba AG, Paananen RO, Hongisto H, Hiidenmaa H, Skottman H, Seppänen-Kaijansinkko R, Mannerström B. Small non-coding RNA landscape of extracellular vesicles from human stem cells. Sci Rep. 2018 Oct 19;8(1):15503.

Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. Redox Biol. 2018 Sep 14;20:1-12.

Pietilä J, Huhtala A, Mäkinen P, Nättinen J, Rajala T, Salmenhaara K, Uusitalo H.Uncorrected visual acuity, postoperative astigmatism, and dry eye symptoms are major determinants of patient satisfaction: a comparative, real-life study of femtosecond laser in situ keratomileusis and small incision lenticule extraction for myopia. Clin Ophthalmol. 2018 Sep 10;12:1741-1755.

Huttunen HJ, Palva JM, Lindberg L, Palva S, Saarela V, Karvonen E, Latvala ML, Liinamaa J, Booms S, Castrén E, Uusitalo H. Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia. Sci Rep. 2018 Aug 27;8(1):12830.

Nättinen J, Jylhä A, Aapola U, Parkkari M, Mikhailova A, Beuerman R, Uusitalo H. Patient stratification in clinical glaucoma trials using the individual tear proteome. Sci Rep. 2018, 8:12038, doi:10.1038/s41598-018-30369-x.

Abu Khamidakh AE, Rodriguez-Martinez A, Kaarniranta K, Kallioniemi A, Skottman H, Hyttinen J, Juuti-Uusitalo K. Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage. Biomed Eng Online. 2018 Jul 31;17(1):102. doi: 10.1186/s12938-018-0535-z.

Jylhä A, Nättinen J, Aapola U, Mikhailova A, Nykter M, Zhou L, Beuerman R, Uusitalo H. Comparison of iTRAQ and SWATH in a clinical study with multiple time points. Clin Proteomics. 2018 Jul 30;15:24. doi: 10.1186/s12014-018-9201-5. eCollection 2018.

Vähätupa M, Nättinen J, Jylhä A, Aapola U, Kataja M, Kööbi P, Järvinen TAH, Uusitalo H, Uusitalo-Järvinen H. SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets. Invest Ophthalmol Vis Sci. 2018 Jul 2;59(8):3294-3306. doi: 10.1167/iovs.18-23831.

Žiniauskaite A, Ragauskas S, Hakkarainen JJ, Rich CC, Baumgartner R, Kalesnykas G, Albers DS, Kaja S. Efficacy of Trabodenoson in a Mouse Keratoconjunctivitis Sicca (KCS) Model for Dry-Eye Syndrome. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):3088-3093. doi: 10.1167/iovs.18-24432.

Hannu Uusitalo, Alexandra Mikhailova, Päivi Sainio ja Seppo Koskinen (2018) Kappale 13.2 Näkö ja kuulo. Teoksessa Päivikki Koponen, Katja Borodulin, Annamari Lundqvist, Katri Sääksjärvi ja Seppo Koskinen, toim. Terveys, toimintakyky ja hyvinvointi Suomessa – FinTerveys 2017 -tutkimus. Terveyden ja hyvinvoinnin laitos (THL). Raportti 4/2018, 236 sivua. Helsinki 2018. ISBN 978-952-343-104-1 (painettu); ISBN 978-952-343-105-8 (verkkojulkaisu).

Piippo N, Korhonen E, Hytti M, Skottman H, Kinnunen K, Josifovska N, Petrovski G, Kaarniranta K, Kauppinen A. Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome. Sci Rep. 2018 Apr 30;8(1):6720.

Sorkio A, Koch L, Koivusalo L, Deiwick A, Miettinen S, Chichkov B, Skottman H. Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks. Biomaterials. 2018 Jul;171:57-71. Epub 2018 Apr 16.

Latonen L, Afyounian E, Jylhä A, Nättinen J, Aapola U, Annala M, Kivinummi K, Tammela T, Beuerman R, Uusitalo H, Nykter M, Visakorpi T. Integrative analysis of the proteome in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression. Nat Commun 2018 Mar 21;9:1176.

NCD Risk Factor Collaboration (NCD-RisC). Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants. Int J Epidemiol. 2018 Mar 19. doi: 10.1093/ije/dyy016. [Epub ahead of print]

Koivusalo L, Karvinen J, Sorsa E, Jönkkäri I, Väliaho J, Kallio P, Ilmarinen T, Miettinen S, Skottman H, Kellomäki M. Hydrazone crosslinked hyaluronan-based hydrogels for therapeutic delivery of adipose stem cells to treat corneal defects. Mater Sci Eng C Mater Biol Appl. 2018 Apr 1;85:68-78. doi: 10.1016/j.msec.2017.12.013. Epub 2017 Dec 18.

Ragauskas S, Kielczewski E, Vance J, Kaja S, Kalesnykas G. In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model. J Vis Exp. 2018 Jan 21;(131).

Vähätupa M, Cordova ZM, Barker H, Aittomäki S, Uusitalo H, Järvinen TAH, Pesu M, Uusitalo-Järvinen H. Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy. Exp Eye Res. 2018 Jan;166:160-167. doi: 10.1016/j.exer.2017.10.013. Epub 2017 Oct 13.

Calejo MT, Ilmarinen T, Skottman H, Kellomäki M. Breath figures in tissue engineering and drug delivery: State-of-the-art and future perspectives. Acta Biomater. 2018 Jan 15;66:44-66. doi: 10.1016/j.actbio.2017.11.043. Epub 2017 Nov 26. Review

Nättinen J, Jylhä A, Aapola U, Enríquez-de-Salamanca A, Pinto-Fraga J, López-Miguel A, González-García MJ, Stern ME, Calonge M, Zhou L, Nykter M, Uusitalo H, Beuerman R. Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. Ocul Surf. 2018; 16(1): 84-92. Epub 2017  Sep 13.

2017

Hongisto H, Ilmarinen T, Vattulainen M, Mikhailova A, Skottman H. Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method. Stem Cell Res Ther. 2017 Dec 29;8(1):291. doi: 10.1186/s13287-017-0738-4.

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017 Dec 16;390(10113):2627-2642. doi: 10.1016/S0140-6736(17)32129-3. Epub 2017 Oct 10.

Gissler M, Ojamo M, Ritvamaa A, Uusitalo H. Lasten silmäsairaudet ja näkövammaisuus Suomessa – mitä rekisterit kertovat. Duodecim 2017, 133(2): 159-66.

Alarautalahti V, Hiltunen M, Onnela N, Nymark S, Kellomäki M, Hyttinen J. Polypyrrole-coated electrodes show thickness-dependent stability in different conditions during 42-day follow-up in vitro. J Biomed Mater Res B Appl Biomater. 2017 Oct 23. doi: 10.1002/jbm.b.34024. [Epub ahead of print]

Vaajanen A, Vapaatalo H. A Single Drop in the Eye – Effects on the Whole Body? Open Ophthalmol J. 2017 Oct 31;11:305-314.

Kalesnykas G, Kokki E, Alasaarela L, Lesch HP, Tuulos T, Kinnunen K, Uusitalo H, Airenne K, Ylä-Herttuala S. Comparative Study Of Adeno-Associated Virus, Adenovirus, Baculovirus And Lentivirus Vectors For Gene Therapy Of The Eyes. Curr Gene Ther. 2017 Oct 3. doi: 10.2174/1566523217666171003170348. [Epub ahead of print]

Skottman H, Muranen J, Lähdekorpi H, Pajula E, Mäkelä K, Koivusalo L, Koistinen A, Uusitalo H, Kaarniranta K, Juuti-Uusitalo K. Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells. Exp Cell Res. 2017 Aug 8. pii: S0014-4827(17)30415-9. doi: 10.1016/j.yexcr.2017.08.004. [Epub ahead of print]

Hongisto H, Jylhä A, Nättinen J, Rieck J, Ilmarinen T, Veréb Z, Aapola U, Beuerman R, Petrovski G, Uusitalo H, Skottman H Comparative proteomic analysis of human embryonic stem cell-derived and primary human retinal pigment epithelium. Sci Rep. 2017 Jul 20;7(1):6016. doi: 10.1038/s41598-017-06233-9.

Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Int J Mol Sci. 2017 May 19;18(5). pii: E1089. doi: 10.3390/ijms18051089.

Leinonen H, Keksa-Goldsteine V, Ragauskas S, Kohlmann P, Singh Y, Savchenko E, Puranen J, Malm T, Kalesnykas G, Koistinaho J, Tanila H, Kanninen KM. Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy. Sci Rep. 2017 May 9;7(1):1597. doi: 10.1038/s41598-017-01716-1.

Lund RJ, Rahkonen N, Malonzo M, Kauko L, Emani MR, Kivinen V, Närvä E, Kemppainen E, Laiho A, Skottman H, Hovatta O, Rasool O, Nykter M, Lähdesmäki H, Lahesmaa R. RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. Stem Cell Reports. 2017 May 9;8(5):1442-1454. doi: 10.1016/j.stemcr.2017.04.016.

Maciulaitiene R, Pakuliene G, Kaja S, Pauza DH, Kalesnykas G, Januleviciene I. Glioprotection of Retinal Astrocytes After Intravitreal Administration of Memantine in the Mouse Optic Nerve Crush Model. Med Sci Monit. 2017 Mar 7;23:1173-1179.

Calejo MT, Ilmarinen T, Vuorimaa-Laukkanen E, Talvitie E, Hakola HM, Skottman H, Kellomäki M. Langmuir-Schaefer film deposition onto honeycomb porous films for retinal tissue engineering. Acta Biomater. 2017 May;54:138-149. doi: 10.1016/j.actbio.2017.02.035. Epub 2017 Feb 20.

Sorkio A, Haimi S, Verdoold V, Juuti-Uusitalo K, Grijpma D, Skottman H. Poly(trimethylene carbonate) as an elastic biodegradable film for human embryonic stem cell-derived retinal pigment epithelial cells. J Tissue Eng Regen Med. 2017 Jan 4. doi: 10.1002/term.2221. [Epub ahead of print]

Helin-Toiviainen M, Rönkkö S, Kaarniranta K, Puustjärvi T, Rekonen P, Ollikainen M, Uusitalo H. Oxidized low-density lipoprotein, lipid and calcium aggregates reveal oxidative stress and inflammation in the conjunctiva of glaucoma patients. Acta Ophthalmol. 2017 Jan 31. doi: 10.1111/aos.13380.

2016

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1,479 population-based measurement studies with 19.1 million participants. The Lancet, 2016, Published Online November 15, 2016, http://dx.doi.org/10.1016/S0140-6736(16)31919-5.

Pietilä J, Huhtala A, Mäkinen P, Poussu A, Rajala T, Savolainen P, Saarinen E, Uusitalo H. Laserit sarveiskalvokirurgiassa. Duodecim 2016;312:2108-2114.

Vähätupa M, Prince S, Vataja S, Mertimo T, Kataja M, Kinnunen K, Marjomäki V, Uusitalo H, Komatsu M, Järvinen T, Uusitalo–Järvinen H. Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy. Invest Ophthalmol Vis Sci 2016, Sep 1;57(11):4898-4909.

Vostatek P, Claridge E, Uusitalo H, Hauta-Kasari M, Fält P, Lensu L. Performance comparison of publicly available retinal blood vessel segmentation methods. Comput Med Imaging Graph. 2016 Jul 25. pii: S0895-6111(16)30070-2. doi: 10.1016/j.compmedimag.2016.07.005. [Epub ahead of print]

NCD Risk Factor Collaboration (NCD-RisC). A century of trends in adult human height. Elife. 2016 Jul 26;5. pii: e13410. doi: 10.7554/eLife.13410.

Berry J, Frederiksen R, Yao Y, Nymark S, Chen J, Cornwall C. Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods. J Neurosci. 2016 Jun 29;36(26):6973-87. doi: 10.1523/JNEUROSCI.3544-15.2016.

Hakkarainen JJ, Reinisalo M, Ragauskas S, Seppänen A, Kaja S, Kalesnykas G. Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells. Int J Pharm. 2016 Jun 29;511(1):73-78. doi: 10.1016/j.ijpharm.2016.06.135. [Epub ahead of print]

Tuulonen A, Kataja M, Syvänen U, Miettunen S, Uusitalo H. Right services to right patients at right time in right setting in Tays Eye Centre. Acta Ophthalmol. 2016 Jul 16. doi: 10.1111/aos.13168. [Epub ahead of print]

Frederiksen R, Nymark S, Kolesnikov AV, Berry JD, Adler L 4th, Koutalos Y, Kefalov VJ, Cornwall MC. Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods. J Gen Physiol. 2016 Jul;148(1):1-11. doi: 10.1085/jgp.201511538.

Abu Khamidakh AE, Dos Santos FC, Skottman H, Juuti-Uusitalo K, Hyttinen J. Semi-automatic Method for Ca2+ Imaging Data Analysis of Maturing Human Embryonic Stem Cells-Derived Retinal Pigment Epithelium. Ann Biomed Eng. 2016 May 25. [Epub ahead of print].

NCD Risk Factor Collaboration (NCD-RisC) Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants Lancet 2016; 387: 1513–30

Uusitalo H, Egorov E, Kaarniranta K, Astakhov Y, Ropo A. Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials. Clin Ophthalmol. 2016 Mar 15;10:445-54. doi: 10.2147/OPTH.S91402. eCollection 2016.

Huhtala A, Pietilä J, Mäkinen P, Uusitalo H. Femtosecond lasers for laser in situ keratomileusis: a systematic review and meta-analysis. Clinical Ophthalmology 2016:10 393–404.

Laatikainen L, Ojamo M, Rudanko SL, Summanen P, Keinänen-Kiukaanniemi S, Tuomilehto J, Herrala S, Uusitalo H. Improving visual prognosis of the diabetic patients during the past 30 years based on the data of the Finnish Register of Visual Impairment. Acta Ophthalmol. 2016 Feb 29. doi: 10.1111/aos.12952. [Epub ahead of print]

Calejo MT, Ilmarinen T, Jongprasitkul H, Skottman H, Kellomäki M. Honeycomb porous films as permeable scaffold materials for human embryonic stem cell-derived retinal pigment epithelium. J Biomed Mater Res A. 2016 Feb 23. doi: 10.1002/jbm.a.35690. [Epub ahead of print]

Nanni L, Paci M, Caetano Dos Santos FL, Skottman H, Juuti-Uusitalo K, Hyttinen J. Texture Descriptors Ensembles Enable Image-Based Classification of Maturation of Human Stem Cell-Derived Retinal Pigmented Epithelium. PLoS One. 2016 Feb 19;11(2):e0149399. doi: 10.1371/journal.pone.0149399. eCollection 2016.

Väätäinen S, Cederberg H, Roine R, Keinänen-Kiukaanniemi S, Saramies J, Uusitalo H, Tuomilehto J, Martikainen J. Does Future Diabetes Risk Impair Current Quality of Life? A Cross-Sectional Study of Health-Related Quality of Life in Relation to the Finnish Diabetes Risk Score (FINDRISC). PLoS One. 2016 Feb 3;11(2):e0147898. doi: 10.1371/journal.pone.0147898. eCollection 2016.

2015

Mikhailova A, Ilmarinen T, Ratnayake A, Petrovski G, Uusitalo H, Skottman H, Rafat M. Human pluripotent stem cell-derived limbal epithelial stem cells on bioengineered matrices for corneal reconstruction. Exp Eye Res 2015, doi: 10.1016/j.exer.2015.11.021.

Ilmarinen T, Hiidenmaa H, Kööbi P, Nymark S, Sorkio A, Wang JH, Stanzel BV, Thieltges F, Alajuuma P, Oksala O, Kataja M, Uusitalo H, Skottman H. Ultrathin Polyimide Membrane as Cell Carrier for Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium. PLoS One. 2015 Nov 25;10(11):e0143669.

Meyer-Rochow VB, Hakko H, Ojamo M, Uusitalo H, Timonen M. Suicides in visually impaired persons: a nation-wide register-linked study from Finland based on thirty years of data. PLoS ONE 10(10): e0141583. doi:10.1471/journal.pone.0141583.

Uusitalo Hannu ja Ojamo Matti (toim.) Näkövammarekisteri 30 vuotta – pieni juhlakirja Näkökulmia suomalaiseen näkemiseen. Näkövammarekisterin julkaisusarja 1/2015, ISSN 1237-8984.

Juuti-Uusitalo K, Nieminen M, Treumer F, Ampuja M, Kallioniemi A, Klettner A, Skottman H. Effects of Cytokine Activation and Oxidative Stress on the Function of the Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Oct 1;56(11):6265-6274.

Mikhailova A, Jylhä A, Rieck J, Nättinen J, Ilmarinen T, Veréb Z, Aapola U, Beuerman R, Petrovski G, Uusitalo H, Skottman H. Comparative proteomics reveals human pluripotent stem cell-derived limbal epithelial stem cells are similar to native ocular surface epithelial cells. Sci. Rep. 2015; 5:14684.

Lukovic D, Artero Castro A, Delgado AB, Bernal Mde L, Luna Pelaez N, Díez Lloret A, Perez Espejo R, Kamenarova K, Fernández Sánchez L, Cuenca N, Cortón M, Avila Fernandez A, Sorkio A, Skottman H, Ayuso C, Erceg S, Bhattacharya SS. Human iPSC derived disease model of MERTK-associated retinitis pigmentosa. Sci Rep. 2015 Aug 11;5:12910.

Vainio I, Abu Khamidakh A, Paci M, Skottman H, Juuti-Uusitalo K, Hyttinen J, Nymark S. Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells. PLoS One. 2015 Jun 12;10(6):e0128434.

Polinati PP, Ilmarinen T, Trokovic R, Hyötyläinen T, Otonkoski T, Suomalainen A, Skottman H, Tyni T. Patient-Specific Induced Pluripotent Stem Cell-Derived RPE Cells: Understanding the Pathogenesis of Retinopathy in Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency. Invest Ophthalmol Vis Sci. 2015 May 1;56(5):3371-82.

Sorkio A, Porter PJ, Juuti-Uusitalo K, Meenan B, Skottman H, Burke G. Surface modified biodegradable electrospun membranes as a carrier for human embryonic stem cell derived retinal pigment epithelial cells. Tissue Eng Part A. 2015 May 6.

Holappa M, Valjakka J, Vaajanen A. Angiotensin(1-7) and ACE2, “The Hot Spots” of Renin-Angiotensin System, Detected in the Human Aqueous Humor. Open Ophthalmol J. 2015 Mar 31;9:28-32.

Sorkio AE, Vuorimaa-Laukkanen EP, Hakola HM, Liang H, Ujula TA, Valle-Delgado JJ, Österberg M, Yliperttula ML, Skottman H. Biomimetic collagen I and IV double layer Langmuir-Schaefer films as microenvironment for human pluripotent stem cell derived retinal pigment epithelial cells. Biomaterials. 2015 May;51:257-69. doi: 10.1016/j.biomaterials.2015.02.005. Epub 2015 Feb 20.

Vaajanen A, Kalesnykas G, Vapaatalo H, Uusitalo H. The expression of Mas-receptor of the renin-angiotensin system in the human eye. Graefes Arch Clin Exp Ophthalmol. 2015 Feb 14.

Välimäki J, Uusitalo H. Matrix metalloproteinases (MMP-1, MMP-2, MMP-3 and MMP-9, and TIMP-1, TIMP-2 and TIMP-3) and markers for vascularization in functioning and non-functioning bleb capsules of glaucoma drainage implants. Acta Ophtahlmol. 2015 Jan 14.

2014

Tong L, Zhou XY, Jylha A, Aapola U, Liu DN, Koh SK, Tian D, Quah J, Uusitalo H, Beuerman RW, Zhou L. Quantitation of 47 human tear proteins using high resolution multiple reaction monitoring (HR-MRM) based-mass spectrometry. J Proteomics. 2014 Dec 19;115C:36-48.

Pfeiffer N, Traverso CE, Lorenz K, Saarela V, Liinamaa J, Uusitalo H, Astakhov Y, Boiko E, Ropo A. A 6-Month Study Comparing Efficacy, Safety, and Tolerability of the Preservative-free Fixed Combination of Tafluprost 0.0015% and Timolol 0.5% versus Each of Its Individual Preservative-Free Components. Adv Ther. 2014 Dec;31(12):1228-46. Epub 2014 Dec 2.

Ragauskas S, Leinonen H, Puranen J, Rönkkö S, Nymark S, Gurevicius K, Lipponen A, Kontkanen O, Puoliväli J, Tanila H, Kalesnykas G. Early Retinal Function Deficit without Prominent Morphological Changes in the R6/2 Mouse Model of Huntington’s Disease. PLoS One. 2014 Dec 3;9(12):e113317.

Skottman H, Uusitalo H. Silmän kantasoluhoidot. Duodecim 2014;130(19):1991-9.

Käpylä E, Sorkio A, Teymouri S, Lahtonen K, Vuori L, Valden M, Skottman H, Kellomäki M, Juuti-Uusitalo K Ormocomp-Modified Glass Increases Collagen Binding and Promotes the Adherence and Maturation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Langmuir. 2014 Nov 24. [Epub ahead of print]

Helin-Toiviainen M, Rönkkö S, Puustjärvi T, Rekonen P, Ollikainen M, Uusitalo H. Conjunctival matrix metalloproteinases and their inhibitors in glaucoma patients. Acta Ophthalmol. 2014 Oct 13. [Epub ahead of print]

Wang JS, Nymark S, Frederiksen R, Estevez ME, Shen SQ, Corbo JC, Cornwall MC, Kefalov VJ. Chromophore supply rate-limits mammalian photoreceptor dark adaptation. J Neurosci. 2014 Aug 20;34(34):11212-21.

Uusitalo H, Siitonen A, Ojamo M. Glaucoma patients in Finland and thier visual prognosis. Data of the Finnish Register of Visual Impairment during the 30 years. European Glaucoma Society Congress, June 2014, Nice, France. (poster)

Polinati P, Ilmarinen T, Trokovic R, Hyötyläinen T, Otonkoski T, Suomalainen A, Skottman H, Tyni TA. Patient specific induced pluripotent stem cells derived RPE cells: understanding the pathogenesis of retinopathy in LCHAD deficiency. Invest Ophthalmol Vis Sci. 2014 Jun 3. pii: IOVS-14-14007. doi: 10.1167/iovs.14-14007.

Tervonen A, Vainio I, Nymark S, Hyttinen J. Prediction of Passive Drug Permeability Across the Blood-Retinal Barrier. Pharm Res.  2014 Mar 13. [Epub ahead of print]

Mikhailova A, Ilmarinen T, Uusitalo H, Skottman H. Small-molecule induction promotes corneal epithelial cell differentiation from human induced pluripotent stem cells.Stem Cell Reports. 2014 Feb 6;2(2):219-31.

2013

Pietilä J, Huhtala A, Mäkinen P, Salmenhaara K, Uusitalo H. Laser-assisted in situ keratomileusis flap creation with the three-dimensional, transportable Ziemer FEMTO LDV model Z6 I femtosecond laser. Acta Ophthalmol. 2013 Dec 26. doi: 10.1111/aos.12333. [Epub ahead of print]

Pietilä J, Huhtala A, Mäkinen P, Uusitalo H. Flap characteristics, predictability, and safety of the Ziemer FEMTO LDV femtosecond laser with the disposable suction ring for LASIK. Eye (Lond). 2013 Nov 15.

Sorkio A, Hongisto H, Kaarniranta K, Uusitalo H, Juuti-Uusitalo K, Skottman H. Structure and barrier properties of human embryonic stem cell derived retinal pigment epithelial cells are affected by extracellular matrix protein coating. Tissue Eng Part A. 2013 Sep 18.

Välimäki J, Uusitalo H. Immunohistochemical analysis of extracellular matrix bleb capsules of functioning and non-functioning glaucoma drainage implants. Acta Ophthalmol. 2013 Sep 11.

Kauppi T, Kämäräinen JK, Lensu L, Kalesnykiene V, Sorri I, Uusitalo H, Kälviäinen H. Constructing benchmark databases and protocols for medical image analysis: diabetic retinopathy. Comput Math Methods Med. 2013;2013:368514.

Kinnunen K, Heinonen SE, Kalesnykas G, Laidinen S, Uusitalo-Järvinen H, Uusitalo H, Ylä-Herttuala S. LDLR-/-ApoB100/100 mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina. Mol Vis. 2013 Aug 4;19:1723-33.

Juuti-Uusitalo K, Delporte C, Grégoire F, Perret J, Huhtala H, Savolainen V, Nymark S, Hyttinen J, Uusitalo H, Willermain F, Skottman H. Aquaporin expression and function in human pluripotent stem cell-derived retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 2013 May 1; 54(5):3510-9.

Abu Khamidakh AE, Juuti-Uusitalo K, Larsson K, Skottman H, Hyttinen J. Intercellular Ca(2+) wave propagation in human retinal pigment epithelium cells induced by mechanical stimulation. Exp Eye Res 2013, 108:129-139.

2012

Onnela N, Lehtonen L, Koski M, Hyttinen J. In vitro electroretinogram for the study of the functionality of differentiated retinal pigment epithelium cells. Med Biol Eng Comput. 2012 Oct 11 [Epub ahead of print].

Ilmarinen T, Laine J, Juuti-Uusitalo K, Numminen J, Seppänen-Suuronen R, Uusitalo H, Skottman H. Towards a defined, serum- and feeder-free culture of stratified human oral mucosal epithelium for ocular surface reconstruction. Acta Ophthalmol. 2012 Sep 11.

Subrizi A, Hiidenmaa H, Ilmarinen T, Nymark S, Dubruel P, Uusitalo H, Yliperttula M, Urtti A, Skottman H. Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes. Biomaterials 33(32): 8047-54. Epub 2012 Aug 11.

Pietilä J, Huhtala A, Mäkinen P, Uusitalo H. Laser in situ keratomileusis enhancements with the Ziemer FEMTO LDV femtosecond laser following previous LASIK treatments. Graefes Arch Clin Exp Ophthalmol. 2012 Jul 20 [Epub ahead of print]

Pertovaara M, Bootorabi F, Kuuslahti M, Uusitalo H, Pukander J, Helin H, Parkkila S. Carbonic anhydrase autoantibodies and sicca symptoms in primary Sjögren´s syndrome. Clin Exp Rheumatol. 2012 May;30(3):456-457.

Pietilä J, Huhtala A, Mäkinen P, Uusitalo H. LASIK operations with the Ziemer FEMTO LDV femtosecond laser flap creation after previous photorefractive keratometry or laser-assisted sub-epithelial keratomileusis. Acta Ophthalmol. 2012 90 (8):e662-3. Epub 2012 May 25.

Juuti-Uusitalo K, Vaajasaari H, Ryhänen T, Narkilahti S, Suuronen R, Mannermaa E, Kaarniranta K, Skottman H. Efflux protein expression in human stem cell-derived retinal pigment epithelial cells. PLoS One 2012, 7:e30089.

Onnela N, Savolainen V, Juuti-Uusitalo K, Vaajasaari H, Skottman H, Hyttinen J. Electric impedance of human embryonic stem cell-derived retinal pigment epithelium. Med Biol Eng Comput. 2012 50(2): 107-16. Epub 2011, Dec 22.

Pellinen P, Huhtala A, Tolonen A, Lokkila J, Mäenpää J, Uusitalo H. The Cytotoxic Effects of Preserved and Preservative-Free Prostaglandin Analogs on Human Corneal and Conjunctival Epithelium In Vitro and the Distribution of Benzalkonium Chloride Homologs in Ocular Surface Tissues In Vivo. Curr Eye Res, 2012 37(2): 145-154. Epub 2011, Nov 3.

2011

Savolainen V, Juuti-Uusitalo K, Onnela N, Vaajasaari H, Narkilahti S, Suuronen R, Skottman H, Hyttinen J. Impedance spectroscopy in monitoring the maturation of stem cell-derived retinal pigment epithelium. Ann Biomed Eng, 2011, 39:3055-69.

Onnela N, Takeshita H, Kaiho Y, Kojima T, Kobayashi R, Tanaka T, Hyttinen J. Comparison of electrode materials for the use of retinal prosthesis. Biomed Mater Eng, 2011, 21:83-97.

Vaajasaari H, Ilmarinen T, Juuti-Uusitalo K, Rajala K, Onnela N, Narkilahti S, Suuronen R, Hyttinen J, Uusitalo H, Skottman H. Towards defined and xeno-free differentiation of functional human pluripotent stem cell – derived retinal pigment epithelial cells. Mol Vis, 2011, 17:558-575.

Rönkkö S, Kaarniranta K, Kalesnykas G, Uusitalo H. Biocompatibility of different poly(lactide-coglycolide) polymers implanted into the subconjunctival space in rats. Ophthalmic Res, 2011, 46:55-65.

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