Uutta tutkimustietoa
2023
Julkunen V, Schwarz C, Kalapudas J, Hallikainen M, Piironen AK, Mannermaa A, Kujala H, Laitinen T, Kosma VM, Paajanen TI, Kälviäinen R, Hiltunen M, Herukka SK, Kärkkäinen S, Kokkola T, Urjansson M; FinnGen; Perola M, Palotie A, Vuoksimaa E, Runz H. A FinnGen pilot clinical recall study for Alzheimer’s disease. Sci Rep. 2023 Aug 3;13(1):12641.
Viippola E, Kuitunen S, Rodosthenous RS, Vabalas A, Hartonen T, Vartiainen P, Demmler J, Vuorinen AL, Liu A, Havulinna AS, Llorens V, Detrois KE, Wang F, Ferro M, Karvanen A, German J, Jukarainen S, Gracia-Tabuenca J, Hiekkalinna T, Koskelainen S, Kiiskinen T, Lahtela E, Lemmelä S, Paajanen T, Siirtola H, Reeve MP, Kristiansson K, Brunfeldt M, Aavikko M, Gen F, Perola M, Ganna A; FinnGen. Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry). Int J Epidemiol. 2023 Aug 2;52(4):e195-e200.
Mäntylä E, Montonen T, Azzari L, Mattola S, Hannula M, Vihinen-Ranta M, Hyttinen J, Vippola M, Foi A, Nymark S, Ihalainen TO. Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina. Mol Biol Cell. 2023 Aug 1;34(9):br13.
Kauppila M, Mörö A, Valle-Delgado JJ, Ihalainen T, Sukki L, Puistola P, Kallio P, Ilmarinen T, Österberg M, Skottman H. Toward Corneal Limbus In Vitro Model: Regulation of hPSC-LSC Phenotype by Matrix Stiffness and Topography During Cell Differentiation Process. Adv Healthc Mater. 2023 Jul 14:e2301396.
Miller EC, Kauko A, Tom SE, Laivuori H, Niiranen T, Bello NA; FinnGen Investigators. Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study. Stroke 2023 Jul;54(7):1798-1805.
Tyrmi JS, Kaartokallio T, Lokki AI, Jääskeläinen T, Kortelainen E, Ruotsalainen S, Karjalainen J, Ripatti S, Kivioja A, Laisk T, Kettunen J, Pouta A, Kivinen K, Kajantie E, Heinonen S, Kere J, Laivuori H; FINNPEC Study Group, FinnGen Project, and the Estonian Biobank Research Team. Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy. JAMA Cardiol. 2023 Jun 7:e231312.
Jones SE, Maisha FI, Strausz SJ, Lammi V, Cade BE, Tervi A, Helaakoski V, Broberg ME; FinnGen; Lane JM, Redline S, Saxena R, Ollila HM. The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections. EBioMedicine. 2023 Jun 5:104630.
Ågren R, Patil S, Zhou X; FinnGen.; Sahlholm K, Pääbo S, Zeberg H. Major Genetic Risk Factors for Dupuytren’s Disease Are Inherited From Neandertals. Mol Biol Evol. 2023 Jun 1;40(6):msad130.
Karema-Jokinen V, Koskela A, Hytti M, Hongisto H, Viheriälä T, Liukkonen M, Torsti T, Skottman H, Kauppinen A, Nymark S, Kaarniranta K. Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients. J Biol Chem. 2023 Jun;299(6):104770.
Puhakka N, Das Gupta S, Leskinen S, Heiskanen M, Nättinen J, Aapola U, Uusitalo H, Pitkänen A. Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury. Neurotrauma Rep. 2023 May 26;4(1):359-366.
Ollila HM, Sharon E, Lin L, Sinnott-Armstrong N, Ambati A, Yogeshwar SM, Hillary RP, Jolanki O, Faraco J, Einen M, Luo G, Zhang J, Han F, Yan H, Dong XS, Li J, Zhang J, Hong SC, Kim TW, Dauvilliers Y, Barateau L, Lammers GJ, Fronczek R, Mayer G, Santamaria J, Arnulf I, Knudsen-Heier S, Bredahl MKL, Thorsby PM, Plazzi G, Pizza F, Moresco M, Crowe C, Van den Eeden SK, Lecendreux M, Bourgin P, Kanbayashi T, Martínez-Orozco FJ, Peraita-Adrados R, Benetó A, Montplaisir J, Desautels A, Huang YS; FinnGen; Jennum P, Nevsimalova S, Kemlink D, Iranzo A, Overeem S, Wierzbicka A, Geisler P, Sonka K, Honda M, Högl B, Stefani A, Coelho FM, Mantovani V, Feketeova E, Wadelius M, Eriksson N, Smedje H, Hallberg P, Hesla PE, Rye D, Pelin Z, Ferini-Strambi L, Bassetti CL, Mathis J, Khatami R, Aran A, Nampoothiri S, Olsson T, Kockum I, Partinen M, Perola M, Kornum BR, Rueger S, Winkelmann J, Miyagawa T, Toyoda H, Khor SS, Shimada M, Tokunaga K, Rivas M, Pritchard JK, Risch N, Kutalik Z, O’Hara R, Hallmayer J, Ye CJ, Mignot EJ. Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy. Nat Commun. 2023 May 15;14(1):2709.
van Velthoven AJH, Utheim TP, Notara M, Bremond-Gignac D, Figueiredo FC, Skottman H, Aberdam D, Daniels JT, Ferrari G, Grupcheva C, Koppen C, Parekh M, Ritter T, Romano V, Ferrari S, Cursiefen C, Lagali N, LaPointe VLS, Dickman MM. Future directions in managing aniridia-associated keratopathy. Surv Ophthalmol. 2023 May 4:S0039-6257(23)00066-8.
Ignatova I, Frolov R, Nymark S. The retinal pigment epithelium displays electrical excitability and lateral signal spreading. BMC Biol. 2023 Apr 17;21(1):84.
Vähätupa M, Nättinen J, Aapola U, Uusitalo-Järvinen H, Uusitalo H, Järvinen TAH. Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy. Int J Mol Sci. 2023 Apr 26;24(9):7914.
Purola P, Koskinen S, Uusitalo H. Impact of vision on generic health-related quality of life – A systematic review. Acta Ophthalmol. 2023 Apr 9.
NCD Risk Factor Collaboration (NCD-RisC). Diminishing benefits of urban living for children and adolescents’ growth and development. Nature. 2023 Mar;615(7954):874-883.
Hellinen L, Hongisto H, Ramsay E, Kaarniranta K, Vellonen KS, Skottman H, Ruponen M Comparison of barrier properties of outer blood-retinal barrier models – human stem cell-based models as a novel tool for ocular drug discovery. Eur J Pharm Biopharm. 2023 Feb 3:S0939-6411(23)00031-0.
Sliz E, Tyrmi JS, Rahmioglu N, Zondervan KT, Becker CM; FinnGen; Uimari O, Kettunen J. Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata. Nat Commun. 2023 Feb 1;14(1):542
2022
Auvinen P, Vehviläinen J, Marjonen H, Modhukur V, Sokka J, Wallén E, Rämö K, Ahola L, Salumets A, Otonkoski T, Skottman H, Ollikainen M, Trokovic R, Kahila H, Kaminen-Ahola N. Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders. BMC Med. 2022 Dec 30;20(1):495.
Mörö A, Samanta S, Honkamäki L, Rangasami VK, Puistola P, Kauppila M, Narkilahti S, Miettinen S, Oommen O, Skottman H. Hyaluronic acid based next generation bioink for 3D bioprinting of human stem cell derived corneal stromal model with innervation. Biofabrication. 2022 Dec 29;15(1).
Parkkari M, Purola P, Uusitalo H. Ocular surface disease signs and symptoms of glaucoma patients and their relation to glaucoma medication in Finland. Eur J Ophthalmol. 2022 Dec 13:11206721221144339.
Purola P, Ojamo M, Gissler M, Uusitalo H. Changes in visual impairment due to diabetic retinopathy during 1980-2019 based on nationwide register data. Diabetes Care, 2022 Sep 1;45(9):2020-2027.
Ruotsalainen SE, Surakka I, Mars N, Karjalainen J, Kurki M, Kanai M, Krebs K, Graham S, Mishra PP, Mishra BH, Sinisalo J, Palta P, Lehtimäki T, Raitakari O; Estonian Biobank Research Team, Milani L; Biobank Japan Project, Okada Y; FinnGen, Palotie A, Widen E, Daly MJ, Ripatti SInframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis. Commun Biol. 2022 Aug 17;5(1):802.
Lotila J, Hyvärinen T, Skottman H, Airas L, Narkilahti S, Hagman S. Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient. Stem Cell Res. 2022 Aug;63:102865.
Purola P, Kaarniranta K, Ojamo M, Gissler M, Uusitalo H. Visual impairment due to age-related macular degeneration during 40 years in Finland and the impact of novel therapies. Acta Ophthalmol. 2022 Aug 1.
Nättinen J, Aapola U, Nukareddy P, Uusitalo H. Clinical Tear Fluid Proteomics-A Novel Tool in Glaucoma Research.Int J Mol Sci. 2022 Jul 23;23(15):8136. Review.
Korkka I, Skottman H, Nymark S.Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2022 Jul 20;11(7):753-766.
Saunajoki A, Auvinen J, Bloigu A, Saramies J, Tuomilehto J, Uusitalo H, Hussi E, Cederberg-Tamminen H, Suija K, Keinänen-Kiukaanniemi S, Timonen M. Elevated One-Hour Post-Load Glucose Is Independently Associated with Albuminuria: A Cross-Sectional Population Study. J Clin Med. 2022 Jul 15;11(14):4124.
Muilu-Mäkelä R, Aapola U, Tienaho J, Uusitalo H, Sarjala T. Antibacterial and oxidative stress-protective effects of five monoterpenes from softwood. Molecules, 2022 Jun 17;27(1):3891.
Peussa H, Kreutzer J, Mäntylä E, Mäki AJ, Nymark S, Kallio P, Ihalainen TO. Pneumatic equiaxial compression device for mechanical manipulation of epithelial cell packing and physiology. PLoS One. 2022 Jun 3;17(6):e0268570.
Välimäki J, Nukareddy P, Uusitalo H, Aapola U. Intraluminal deposits: A rare cause of glaucoma drainage implant total obstruction. Eur J Ophthalmol., 2022 May 16:11206721221100074. Online ahead of print.
Pelttari S, Väärämäki S, Vanakker O, Verschuere S, Uusitalo H, Huhtala H, Hinkka T, Pärsti I, Nevalainen PI. Various vascular malformations are prevalent in Finnish pseudoaxanthoma elasticum (PXE) patients: a national registry study. Orphanet J Rare Dis 2022; 17(1):185.
Fadjukov J, Wienbar S, Hakanen S, Aho V, Vihinen-Ranta M, Ihalainen TO, Schwartz GW, Nymark S. Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium. J Gen Physiol. 2022 Apr 4;154(4):e202112916.
Purola P, Nättinen J, Ojamo M, Rissanen H, Gissler M, Koskinen S, Uusitalo H. Prevalence and 11-year incidence of cataract and cataract surgery and the effects of socio-demographic and lifestyle factors. Clin Ophthalmol. 2022 Apr 20;16:1183-1195.
Saramies J, Koiranen M, Auvinen J, Uusitalo H, Hussi E, Becker S, Keinänen-Kiukaanniemi S, Tuomilehto J, Suija K. A natural history of erectile dysfunction in elderly men: a population-based twelve-year prospective study. J Clin Med. 2022 Apr 12;11(8):2146.
Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC et al. New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nat Genet. 2022 Apr;54(4):412-436.
Aapola U, Nättinen J, Suurkuukka I, Tuomilehto J, Keinänen-Kiukaanniemi S, Saramies J, Uusitalo H.Ocular surface health of the Finnish elderly population. Acta Ophthalmol. 2022 Mar 24. doi: 10.1111/aos.15130.
Tamlander M, Mars N, Pirinen M, FinnGen, Widen E, Ripatti S. Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes. Commun Biol. 2022 Feb 23;5(1):158.
Purola PKM, Nättinen JE, Parkkari MM, Ojamo MUI, Koskinen SVP, Rissanen HA, Sainio PRJ, Uusitalo HMT. Improving health-related quality of life in glaucoma during 11 years and its association with vision loss and treatment of the disease. Acta Ophthalmol. 2022 Feb;100(1):e221-e232.
Viheriälä T, Hongisto H, Sorvari J, Skottman H, Nymark S, Ilmarinen T. Cell maturation influences the ability of hESC-RPE to tolerate cellular stress. Stem Cell Res Ther. 2022 Jan 24;13(1):30.
2021
Saramies J, Koiranen M, Auvinen J, Uusitalo H, Hussi E, Cederberg H, Keinänen-Kiukaanniemi S, Tuomilehto J. 22-year trends in dysglycemia and body mass index: A population-based cohort study in Savitaipale, Finland. Prim Care Diabetes. 2021 Dec;15(6):977-984.
Palomäki A; FinnGen Rheumatology Clinical Expert Group, Palotie A, Koskela J, Eklund KK, Pirinen M; FinnGen, Ripatti S, Laitinen T, Mars N. Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers. Ann Rheum Dis. 2021 Dec;80(12):1530-1536.
Vattulainen M, Ilmarinen T, Viheriälä T, Jokinen V, Skottman H. Corneal epithelial differentiation of human pluripotent stem cells generates ABCB5+ and ∆Np63α+ cells with limbal cell characteristics and high wound healing capacity. Stem Cell Res Ther. 2021 Dec 20;12(1):609.
Nättinen J, Aapola U, Nukareddy P, Uusitalo H. Looking deeper into ocular surface health: an introduction to clinical tear proteomics analysis. Acta Ophthalmol. 2021 Nov 8. doi: 10.1111/aos.15059. Online ahead of print.
Mäkelä E, Venesvirta H, Ilves M, Lylykangas J, Rantanen V, Uusitalo H, Verho J, Vehkaoja A, Lekkala J, Surakka V, Rautiainen M. Electrically Induced Blink for the Prevention of Ocular Symptoms and Blurred Vision in Patients With Acute Facial Nerve Palsy. Ear Nose Throat J. 2021 Oct 29:1455613211048576. doi: 10.1177/01455613211048576. Online ahead of print.
Garifullin A, Lensu L, Uusitalo H. Deep Bayesian baseline for segmenting diabetic retinopathy lesions: Advances and challenges. Comput Biol Med. 2021 Sep;136:104725.
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021 Sep 11;398(10304):957-980.
Vaajanen A, Purola P, Ojamo M, Gissler M, Uusitalo H. Changes in incidence and severity of visual impairment due to glaucoma during 40 years – a register-based study in Finland. Acta Ophthalmol. 2021 Sep 30.
Purola P, Nättinen J, Ojamo M, Koskinen S, Rissanen H, Sainio P, Uusitalo H. Prevalence and 11-year incidence of common eye diseases and their relation to health-related quality of life, mental health, and visual impairment. Qual Life Res 2021 Aug;30(8):2311-2327.
Viljanen A, Koskela K, Koskela H, Tuuminen R, Uusitalo H. One-year Results of Health-related and Vision-related Quality of Life after Clear Lens Extraction and Multifocal IOL Implantation. Am J Ophthalmol. 2021 Jul;227:240-244.
Català P, Thuret G, Skottman H, Mehta JS, Parekh M, Ní Dhubhghaill S, Collin RWJ, Nuijts RMMA, Ferrari S, LaPointe VLS, Dickman MM. Approaches for corneal endothelium regenerative medicine. Prog Retin Eye Res. 2021 Jul 6:100987.
Liu Z, Ilmarinen T, Tan GSW, Hongisto H, Wong EYM, Tsai ASH, Al-Nawaiseh S, Holder GE, Su X, Barathi VA, Skottman H, Stanzel BV. Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model. Stem Cell Res Ther. 2021 Jul 27;12(1):423.
Liuska PJ, Lemmelä S, Havulinna AS, Kaarniranta K, Uusitalo H, Laivuori H, Kiiskinen T, Daly MJ, Palotie A, Turunen JA; FinnGen Consortium. Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population. JAMA Ophthalmol. 2021 Jul 1;139(7):762-768.
Zekavat SM, Lin SH, Bick AG, Liu A, Paruchuri K, et al. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nat Med. 2021 Jun;27(6):1012-1024.
Hytti M, Korhonen E, Hongisto H, Kaarniranta K, Skottman H, Kauppinen A. Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration. Int J Mol Sci. 2021 Jun 24;22(13):6800.
Natarajan P, Pampana A, Graham SE, Ruotsalainen SE, Perry JA, et al. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nat Commun. 2021 Apr 12;12(1):2182.
Arzalluz-Luque Á, Cabrera JL, Skottman H, Benguria A, Bolinches-Amorós A, Cuenca N, Lupo V, Dopazo A, Tarazona S, Delás B, Carballo M, Pascual B, Hernan I, Erceg S, Lukovic D. Mutant PRPF8 Causes Widespread Splicing Changes in Spliceosome Components in Retinitis Pigmentosa Patient iPSC-Derived RPE Cells. Front Neurosci. 2021 Apr 29;15:636969.
Julku H, Rouhinen S, Huttunen HJ, Lindberg L, Liinamaa J, Saarela V, Karvonen E, Booms S, Mäkelä JP, Uusitalo H, Castrén E, Palva JM, Palva S. Reduced evoked activity and cortical oscillations are correlated with anisometric amblyopia and impairment of visual acuity. Sci Rep. 2021 Apr 15;11(1):8310.
Anton-Sales I, Koivusalo L, Skottman H, Laromaine A, Roig A. Limbal Stem Cells on Bacterial Nanocellulose Carriers for Ocular Surface Regeneration. Small. 2021 Mar;17(10):e2003937.
NCD Risk Factor Collaboration (NCD-RisC). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. Elife 2021; 10:e60060.
Ruotsalainen SE, Partanen JJ, Cichonska A, Lin J, Benner C, Surakka I; FinnGen, Reeve MP, Palta P, Salmi M, Jalkanen S, Ahola-Olli A, Palotie A, Salomaa V, Daly MJ, Pirinen M, Ripatti S, Koskela J. An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease. Eur J Hum Genet. 2021 Feb;29(2):309-324.
Grönroos P, Ilmarinen T, Skottman H. Directed Differentiation of Human Pluripotent Stem Cells towards Corneal Endothelial-Like Cells under Defined Conditions. Cells. 2021 Feb 5;10(2):331.
Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, Pendergrass S, et al. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun. 2021 Feb 24;12(1):1258.
Sinnott-Armstrong, N., Tanigawa, Y., Amar, D., Mars, N., Benner, C., Aguirre, M., Venkataraman, G. R., Wainberg, M., Ollila, H. M., Kiiskinen, T., Havulinna, A. S., Pirruccello, J. P., Qian, J., Shcherbina, A., Rodriguez, F., Assimes, T. L., Agarwala, V., Tibshirani, R., Hastie, T., Ripatti, S. & 18 others. Genetics of 35 blood and urine biomarkers in the UK Biobank. Nat Genet 2021, 53, 2, 185-194.
Vaajanen A, Nättinen J, Aapola U, Gielen F, Uusitalo H. The effect of successful trabeculectomy on the ocular surface and tear proteomics-a prospective cohort study with 1-year follow-up. Acta Ophthalmol. 2021:99:160-170.
Viheriälä T, Sorvari J, Ihalainen TO, Mörö A, Grönroos P, Schlie-Wolter S, Chichkov B, Skottman H, Nymark S, Ilmarinen T. Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE. Sci Rep. 2021 Jan 13;11(1):933.
Konstas AG, Schmetterer L, Katsanos A, Hutnik CML, Holló G, Quaranta L, Teus MA, Uusitalo H, Pfeiffer N, Katz LJ. Dorzolamide/Timolol Fixed Combination: Learning from the Past and Looking Toward the Future. Adv Ther. 2021 Jan;38(1):24-51.
Strausz S, Kiiskinen T, Broberg M, Ruotsalainen S, Koskela J, Bachour A; FinnGen, Palotie A, Palotie T, Ripatti S, Ollila HM. Sleep apnoea is a risk factor for severe COVID-19.BMJ Open Respir Res. 2021 Jan;8(1):e000845.
2020
Mars N, Widén E, Kerminen S, Meretoja T, Pirinen M, Della Briotta Parolo P, Palta P; FinnGen, Palotie A, Kaprio J, Joensuu H, Daly M, Ripatti S.The role of polygenic risk and susceptibility genes in breast cancer over the course of life. Nat Commun. 2020 Dec 14;11(1):6383.
NCD Risk Factor Collaboration (NCD-RisC). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. Lancet. 2020 Nov 7;396(10261):1511-1524.
Saramies, J., Uusitalo, H., Tuomilehto, J. & Keinänen-Kiukaanniemi, S. Diabeteksen 22 vuoden seurantatutkimus. ERIKOISLÄÄKÄRI 2020 30, 2, 51-55.
Nättinen J, Mäkinen P, Aapola U, Orsila L, Pietilä J, Uusitalo H. Early changes in tear film protein profiles after femtosecond LASIK surgery. Clin Proteomics. 2020 Oct 19;17:36.
Fedele C, Mäntylä E, Belardi B, Hamkins-Indik T, Cavalli S, Netti PA, Fletcher DA, Nymark S, Priimagi A, Ihalainen TO. Azobenzene-based sinusoidal surface topography drives focal adhesion confinement and guides collective migration of epithelial cells. Sci Rep. 2020 Sep 18;10(1):15329.
Bao, E. L., Nandakumar, S. K., Liao, X., Bick, A. G., Karjalainen, J., Tabaka, M., Gan, O. I., Havulinna, A. S., Kiiskinen, T. T. J., Lareau, C. A., de Lapuente Portilla, A. L., Li, B., Emdin, C., Codd, V., Nelson, C. P., Walker, C. J., Churchhouse, C., de la Chapelle, A. & 26 others. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature 2020, 586, 7831, 769-775.
Hongisto H, Dewing JM, Christensen DR, Scott J, Cree AJ, Nättinen J, Määttä J, Jylhä A, Aapola U, Uusitalo H, Kaarniranta K, Ratnayaka JA, Skottman H, Lotery AJ. In vitro stem cell modelling demonstrates a proof-of-concept for excess functional mutant TIMP3 as the cause of Sorsby fundus dystrophy. J Pathol. 2020, 252(2):138-150.
Ketola, A., Lammi, T. & Uusitalo, H. Näkökyky, työkyky ja ammatillinen kuntoutus. Työterveyslääkäri 2020, 38 (1) 57-60.
Ramsay E, Raviña M, Sarkhel S, Hehir S, Cameron NR, Ilmarinen T, Skottman H, Kjems J, Urtti A, Ruponen M, Subrizi A. Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models. Pharmaceutics. 2020 Jul 16;12(7):667.
Tienaho J, Karonen M, Muilu-Mäkelä R, Kaseva J, de Pedro N, Vicente F, Genilloud O, Aapola U, Uusitalo H, Vuolteenaho K, Franzén R, Wähälä K, Karp M, Santala V, Sarjala T. Bioactive Properties of the Aqueous Extracts of Endophytic Fungi Associated with Scots Pine (Pinus sylvestris) Roots. Planta Med. 2020 86(13-14):1009-1024.
NCD Risk Factor Collaboration (NCD-RisC). Repositioning of the global epicentre of non-optimal cholesterol. Nature. 2020 Jun;582(7810):73-77.
Garifullin A., Lensu L., Uusitalo H. On the Uncertainty of Retinal Artery-Vein Classification with Dense Fully-Convolutional Neural Networks. In: Blanc-Talon J., Delmas P., Philips W., Popescu D., Scheunders P. (eds) Advanced Concepts for Intelligent Vision Systems. ACIVS 2020. pp 262-273. Lecture Notes in Computer Science, vol 12002. Springer, Cham
Kaplan S., Lensu L., Laaksonen L., Uusitalo H. Evaluation of Unconditioned Deep Generative Synthesis of Retinal Images. In: Blanc-Talon J., Delmas P., Philips W., Popescu D., Scheunders P. (eds) Advanced Concepts for Intelligent Vision Systems. ACIVS 2020. pp 262-273, Lecture Notes in Computer Science, vol 12002. Springer, Cham
Tanigawa, Y., Wainberg, M., Karjalainen, J., Kiiskinen, T., Venkataraman, G., Lemmelä, S., Turunen, J. A., Graham, R. R., Havulinna, A. S., Perola, M., Palotie, A., Daly, M. J., Rivas, M. A., FinnGen, Savinainen, K., Laaksonen, R., Peltola, J., Jussila, A., Isomäki, P., Laitinen, T. & 7 others. are protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma. PLoS Genetics 2020, 16, 5, e1008682.
NCD Risk Factor Collaboration. National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries. Int J Epidemiol. 2020 49(1):173-192.
Kaarniranta K, Uusitalo H, Blasiak J, Felszeghy S, Kannan R, Kauppinen A, Salminen A, Sinha D, Ferrington D. Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Prog Retin Eye Res. 2020 Apr 13:100858.
Karesvuo P, Hakkala L, Kaarniranta K, Uusitalo H, Ojamo M, Tuuminen R. Correlation between the rate of intravitreal injections, use of aflibercept as a second-line treatment and visual impairment for wet AMD in Finland. Acta Ophthalmol. 2020 98(5):472-476..
Parkkari M, Taipale J, Uusitalo H. Comparing glaucoma medications and general demographics in a sample of glaucoma patients treated in private practice with nationwide registry data in Finland. Acta Ophthalmol. 2020 98(5):449-454.
Nättinen J, Aapola U, Jylhä A, Vaajanen A, Uusitalo H. Comparison of Capillary and Schirmer Strip Tear Fluid Sampling Methods Using SWATH-MS Proteomics Approach. Trans Vis Sci Tech 2020, 9(3):16.
Hellinen L, Hongisto H, Ramsay E, Kaarniranta K, Vellonen KS, Skottman H, Ruponen M. Drug Flux Across RPE Cell Models: The Hunt for An Appropriate Outer Blood-Retinal Barrier Model for Use in Early Drug Discovery. Pharmaceutics. 2020 Feb 19;12(2). pii: E176.
Calejo MT, Saari J, Vuorenpää H, Vuorimaa-Laukkanen E, Kallio P, Aalto-Setälä K, Miettinen S, Skottman H, Kellomäki M, Juuti-Uusitalo K. Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films. Acta Biomater. 2020 Jan 1;101:327-343
2019
Taipale J, Mikhailova A, Ojamo M, Nättinen J, Väätäinen S, Gissler M, Koskinen S, Rissanen H, Sainio P, Uusitalo H. Low vision status and declining vision decrease Health-Related Quality of Life: Results from a nationwide 11-year follow-up study. Qual Life Res. 2019 Dec;28(12):3225-3236.
Sorvari J, Viheriälä T, Ilmarinen T, Ihalainen TO, Nymark S. Analysis of ATP-Induced Ca2+ Responses at Single Cell Level in Retinal Pigment Epithelium Monolayers. Adv Exp Med Biol. 2019;1185:525-530.
Tabassum R, Rämö JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Söderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M; FinnGen Project, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S. Genetic architecture of human plasma lipidome and its link to cardiovascular disease. Nat Commun. 2019 Sep 24;10(1):4329.
Koivusalo L, Kauppila M, Samanta S, Parihar VS, Ilmarinen T, Miettinen S, Oommen OP, Skottman H. Tissue adhesive hyaluronic acid hydrogels for sutureless stem cell delivery and regeneration of corneal epithelium and stroma. Biomaterials. 2019 Sep 23;225:119516.
Vuori N, Sandholm N, Kumar A, Hietala K, Syreeni A, Forsblom C, Juuti-Uusitalo K, Skottman H, Imamura M, Maeda S, Summanen PA, Lehto M, Groop PH; FinnDiane Study. CACNB2 is a Novel Susceptibility Gene for Diabetic Retinopathy in Type 1 Diabetes. Diabetes. 2019 Aug 22. pii: db190130.
Johansson JK, Karema-Jokinen VI, Hakanen S, Jylhä A, Uusitalo H, Vihinen-Ranta M, Skottman H, Ihalainen TO, Nymark S. Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium. BMC Biol. 2019 Aug 15;17(1):63.
Vattulainen M, Ilmarinen T, Koivusalo L, Viiri K, Hongisto H, Skottman H. Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential. Stem Cell Res Ther. 2019 Aug 5;10(1):236.
Kiamehr M, Klettner A, Richert E, Koskela A, Koistinen A, Skottman H, Kaarniranta K, Aalto-Setälä K, Juuti-Uusitalo K. Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients. Int J Mol Sci. 2019 Aug 1;20(15). pii: E3773.
NCD Risk Factor Collaboration .National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries. Int J Epidemiol. 2019 Jul 18.
Mäkinen P, Huhtala A, Pietilä J, Nättinen J, Rajala T, Salmenhaara K, Udratov M, Uusitalo H. Patient satisfaction and self-reported dry eye symptoms in hyperopic patients treated with femtosecond laser in situ keratomileusis. Clin Ophthalmol. 2019 Apr 26;13:741-754.
NCD Risk Factor Collaboration (NCD-RisC). Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature. 2019 May;569(7755):260-264.
Alarautalahti V, Ragauskas S, Hakkarainen JJ, Uusitalo-Järvinen H, Uusitalo H, Hyttinen J, Kalesnykas G, Nymark S. Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology. Invest Ophthalmol Vis Sci. 2019 May 1;60(6):1914-1927.
Tervonen A, Ihalainen TO, Nymark S, Hyttinen J. Structural dynamics of tight junctions modulate the properties of the epithelial barrier. PLoS One. 2019 Apr 9;14(4):e0214876.
Haagdorens M, Cėpla V, Melsbach E, Koivusalo L, Skottman H, Griffith M, Valiokas R, Zakaria N, Pintelon I, Tassignon MJ. In Vitro Cultivation of Limbal Epithelial Stem Cells on Surface-Modified Crosslinked Collagen Scaffolds. Stem Cells Int. 2019 Apr 1;2019:7867613
Nättinen J, Jylhä A, Aapola U, Mäkinen P, Beuerman R, Pietilä J, Vaajanen A, Uusitalo H. Age-associated changes in human tear proteome. Clin Proteomics. 2019 Mar 30;16:11.
Žiniauskaitė A, Ragauskas S, Ghosh AK, Thapa R, Roessler AE, Koulen P, Kalesnykas G, Hakkarainen JJ, Kaja S. Manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin, a superoxide dismutase mimetic, reduces disease severity in in vitro and in vivo models for dry-eye disease. Ocul Surf. 2019 Feb 23. pii: S1542-0124(18)30233-7.
Szatmári-Tóth M, Ilmarinen T, Mikhailova A, Skottman H, Kauppinen A, Kaarniranta K, Kristóf E, Lytvynchuk L, Veréb Z, Fésüs L, Petrovski G. Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation. Int J Mol Sci. 2019 Feb 20;20(4). pii: E926.
2018
Ilmarinen T, Thieltges F, Hongisto H, Juuti-Uusitalo K, Koistinen A, Kaarniranta K, Brinken R, Braun N, Holz FG, Skottman H, Stanzel BV. Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits. Acta Ophthalmol. 2018 Dec 28.
Korkka I, Viheriälä T, Juuti-Uusitalo K, Uusitalo-Järvinen H, Skottman H, Hyttinen J, Nymark S. Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2018 Nov 4. doi: 10.1002/sctm.18-0026.
Hongisto H, Vattulainen M, Ilmarinen T, Mikhailova A, Skottman H. Efficient and Scalable Directed Differentiation of Clinically Compatible Corneal Limbal Epithelial Stem Cells from Human Pluripotent Stem Cells. J Vis Exp. 2018 Oct 24;(140).
Kaur S, Abu-Shahba AG, Paananen RO, Hongisto H, Hiidenmaa H, Skottman H, Seppänen-Kaijansinkko R, Mannerström B. Small non-coding RNA landscape of extracellular vesicles from human stem cells. Sci Rep. 2018 Oct 19;8(1):15503.
Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. Redox Biol. 2018 Sep 14;20:1-12.
Pietilä J, Huhtala A, Mäkinen P, Nättinen J, Rajala T, Salmenhaara K, Uusitalo H.Uncorrected visual acuity, postoperative astigmatism, and dry eye symptoms are major determinants of patient satisfaction: a comparative, real-life study of femtosecond laser in situ keratomileusis and small incision lenticule extraction for myopia. Clin Ophthalmol. 2018 Sep 10;12:1741-1755.
Huttunen HJ, Palva JM, Lindberg L, Palva S, Saarela V, Karvonen E, Latvala ML, Liinamaa J, Booms S, Castrén E, Uusitalo H. Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia. Sci Rep. 2018 Aug 27;8(1):12830.
Nättinen J, Jylhä A, Aapola U, Parkkari M, Mikhailova A, Beuerman R, Uusitalo H. Patient stratification in clinical glaucoma trials using the individual tear proteome. Sci Rep. 2018, 8:12038, doi:10.1038/s41598-018-30369-x.
Abu Khamidakh AE, Rodriguez-Martinez A, Kaarniranta K, Kallioniemi A, Skottman H, Hyttinen J, Juuti-Uusitalo K. Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage. Biomed Eng Online. 2018 Jul 31;17(1):102. doi: 10.1186/s12938-018-0535-z.
Jylhä A, Nättinen J, Aapola U, Mikhailova A, Nykter M, Zhou L, Beuerman R, Uusitalo H. Comparison of iTRAQ and SWATH in a clinical study with multiple time points. Clin Proteomics. 2018 Jul 30;15:24. doi: 10.1186/s12014-018-9201-5. eCollection 2018.
Vähätupa M, Nättinen J, Jylhä A, Aapola U, Kataja M, Kööbi P, Järvinen TAH, Uusitalo H, Uusitalo-Järvinen H. SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets. Invest Ophthalmol Vis Sci. 2018 Jul 2;59(8):3294-3306. doi: 10.1167/iovs.18-23831.
Žiniauskaite A, Ragauskas S, Hakkarainen JJ, Rich CC, Baumgartner R, Kalesnykas G, Albers DS, Kaja S. Efficacy of Trabodenoson in a Mouse Keratoconjunctivitis Sicca (KCS) Model for Dry-Eye Syndrome. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):3088-3093. doi: 10.1167/iovs.18-24432.
Hannu Uusitalo, Alexandra Mikhailova, Päivi Sainio ja Seppo Koskinen (2018) Kappale 13.2 Näkö ja kuulo. Teoksessa Päivikki Koponen, Katja Borodulin, Annamari Lundqvist, Katri Sääksjärvi ja Seppo Koskinen, toim. Terveys, toimintakyky ja hyvinvointi Suomessa – FinTerveys 2017 -tutkimus. Terveyden ja hyvinvoinnin laitos (THL). Raportti 4/2018, 236 sivua. Helsinki 2018. ISBN 978-952-343-104-1 (painettu); ISBN 978-952-343-105-8 (verkkojulkaisu).
Piippo N, Korhonen E, Hytti M, Skottman H, Kinnunen K, Josifovska N, Petrovski G, Kaarniranta K, Kauppinen A. Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome. Sci Rep. 2018 Apr 30;8(1):6720.
Sorkio A, Koch L, Koivusalo L, Deiwick A, Miettinen S, Chichkov B, Skottman H. Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks. Biomaterials. 2018 Jul;171:57-71. Epub 2018 Apr 16.
Latonen L, Afyounian E, Jylhä A, Nättinen J, Aapola U, Annala M, Kivinummi K, Tammela T, Beuerman R, Uusitalo H, Nykter M, Visakorpi T. Integrative analysis of the proteome in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression. Nat Commun 2018 Mar 21;9:1176.
NCD Risk Factor Collaboration (NCD-RisC). Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants. Int J Epidemiol. 2018 Mar 19. doi: 10.1093/ije/dyy016. [Epub ahead of print]
Koivusalo L, Karvinen J, Sorsa E, Jönkkäri I, Väliaho J, Kallio P, Ilmarinen T, Miettinen S, Skottman H, Kellomäki M. Hydrazone crosslinked hyaluronan-based hydrogels for therapeutic delivery of adipose stem cells to treat corneal defects. Mater Sci Eng C Mater Biol Appl. 2018 Apr 1;85:68-78. doi: 10.1016/j.msec.2017.12.013. Epub 2017 Dec 18.
Ragauskas S, Kielczewski E, Vance J, Kaja S, Kalesnykas G. In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model. J Vis Exp. 2018 Jan 21;(131).
Vähätupa M, Cordova ZM, Barker H, Aittomäki S, Uusitalo H, Järvinen TAH, Pesu M, Uusitalo-Järvinen H. Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy. Exp Eye Res. 2018 Jan;166:160-167. doi: 10.1016/j.exer.2017.10.013. Epub 2017 Oct 13.
Calejo MT, Ilmarinen T, Skottman H, Kellomäki M. Breath figures in tissue engineering and drug delivery: State-of-the-art and future perspectives. Acta Biomater. 2018 Jan 15;66:44-66. doi: 10.1016/j.actbio.2017.11.043. Epub 2017 Nov 26. Review
Nättinen J, Jylhä A, Aapola U, Enríquez-de-Salamanca A, Pinto-Fraga J, López-Miguel A, González-García MJ, Stern ME, Calonge M, Zhou L, Nykter M, Uusitalo H, Beuerman R. Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. Ocul Surf. 2018; 16(1): 84-92. Epub 2017 Sep 13.
2017
Hongisto H, Ilmarinen T, Vattulainen M, Mikhailova A, Skottman H. Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method. Stem Cell Res Ther. 2017 Dec 29;8(1):291. doi: 10.1186/s13287-017-0738-4.
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017 Dec 16;390(10113):2627-2642. doi: 10.1016/S0140-6736(17)32129-3. Epub 2017 Oct 10.
Gissler M, Ojamo M, Ritvamaa A, Uusitalo H. Lasten silmäsairaudet ja näkövammaisuus Suomessa – mitä rekisterit kertovat. Duodecim 2017, 133(2): 159-66.
Alarautalahti V, Hiltunen M, Onnela N, Nymark S, Kellomäki M, Hyttinen J. Polypyrrole-coated electrodes show thickness-dependent stability in different conditions during 42-day follow-up in vitro. J Biomed Mater Res B Appl Biomater. 2017 Oct 23. doi: 10.1002/jbm.b.34024. [Epub ahead of print]
Vaajanen A, Vapaatalo H. A Single Drop in the Eye – Effects on the Whole Body? Open Ophthalmol J. 2017 Oct 31;11:305-314.
Kalesnykas G, Kokki E, Alasaarela L, Lesch HP, Tuulos T, Kinnunen K, Uusitalo H, Airenne K, Ylä-Herttuala S. Comparative Study Of Adeno-Associated Virus, Adenovirus, Baculovirus And Lentivirus Vectors For Gene Therapy Of The Eyes. Curr Gene Ther. 2017 Oct 3. doi: 10.2174/1566523217666171003170348. [Epub ahead of print]
Skottman H, Muranen J, Lähdekorpi H, Pajula E, Mäkelä K, Koivusalo L, Koistinen A, Uusitalo H, Kaarniranta K, Juuti-Uusitalo K. Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells. Exp Cell Res. 2017 Aug 8. pii: S0014-4827(17)30415-9. doi: 10.1016/j.yexcr.2017.08.004. [Epub ahead of print]
Hongisto H, Jylhä A, Nättinen J, Rieck J, Ilmarinen T, Veréb Z, Aapola U, Beuerman R, Petrovski G, Uusitalo H, Skottman H Comparative proteomic analysis of human embryonic stem cell-derived and primary human retinal pigment epithelium. Sci Rep. 2017 Jul 20;7(1):6016. doi: 10.1038/s41598-017-06233-9.
Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Int J Mol Sci. 2017 May 19;18(5). pii: E1089. doi: 10.3390/ijms18051089.
Leinonen H, Keksa-Goldsteine V, Ragauskas S, Kohlmann P, Singh Y, Savchenko E, Puranen J, Malm T, Kalesnykas G, Koistinaho J, Tanila H, Kanninen KM. Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy. Sci Rep. 2017 May 9;7(1):1597. doi: 10.1038/s41598-017-01716-1.
Lund RJ, Rahkonen N, Malonzo M, Kauko L, Emani MR, Kivinen V, Närvä E, Kemppainen E, Laiho A, Skottman H, Hovatta O, Rasool O, Nykter M, Lähdesmäki H, Lahesmaa R. RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. Stem Cell Reports. 2017 May 9;8(5):1442-1454. doi: 10.1016/j.stemcr.2017.04.016.
Maciulaitiene R, Pakuliene G, Kaja S, Pauza DH, Kalesnykas G, Januleviciene I. Glioprotection of Retinal Astrocytes After Intravitreal Administration of Memantine in the Mouse Optic Nerve Crush Model. Med Sci Monit. 2017 Mar 7;23:1173-1179.
Calejo MT, Ilmarinen T, Vuorimaa-Laukkanen E, Talvitie E, Hakola HM, Skottman H, Kellomäki M. Langmuir-Schaefer film deposition onto honeycomb porous films for retinal tissue engineering. Acta Biomater. 2017 May;54:138-149. doi: 10.1016/j.actbio.2017.02.035. Epub 2017 Feb 20.
Sorkio A, Haimi S, Verdoold V, Juuti-Uusitalo K, Grijpma D, Skottman H. Poly(trimethylene carbonate) as an elastic biodegradable film for human embryonic stem cell-derived retinal pigment epithelial cells. J Tissue Eng Regen Med. 2017 Jan 4. doi: 10.1002/term.2221. [Epub ahead of print]
Helin-Toiviainen M, Rönkkö S, Kaarniranta K, Puustjärvi T, Rekonen P, Ollikainen M, Uusitalo H. Oxidized low-density lipoprotein, lipid and calcium aggregates reveal oxidative stress and inflammation in the conjunctiva of glaucoma patients. Acta Ophthalmol. 2017 Jan 31. doi: 10.1111/aos.13380.
2016
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1,479 population-based measurement studies with 19.1 million participants. The Lancet, 2016, Published Online November 15, 2016, http://dx.doi.org/10.1016/S0140-6736(16)31919-5.
Pietilä J, Huhtala A, Mäkinen P, Poussu A, Rajala T, Savolainen P, Saarinen E, Uusitalo H. Laserit sarveiskalvokirurgiassa. Duodecim 2016;312:2108-2114.
Vähätupa M, Prince S, Vataja S, Mertimo T, Kataja M, Kinnunen K, Marjomäki V, Uusitalo H, Komatsu M, Järvinen T, Uusitalo–Järvinen H. Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy. Invest Ophthalmol Vis Sci 2016, Sep 1;57(11):4898-4909.
Vostatek P, Claridge E, Uusitalo H, Hauta-Kasari M, Fält P, Lensu L. Performance comparison of publicly available retinal blood vessel segmentation methods. Comput Med Imaging Graph. 2016 Jul 25. pii: S0895-6111(16)30070-2. doi: 10.1016/j.compmedimag.2016.07.005. [Epub ahead of print]
NCD Risk Factor Collaboration (NCD-RisC). A century of trends in adult human height. Elife. 2016 Jul 26;5. pii: e13410. doi: 10.7554/eLife.13410.
Berry J, Frederiksen R, Yao Y, Nymark S, Chen J, Cornwall C. Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods. J Neurosci. 2016 Jun 29;36(26):6973-87. doi: 10.1523/JNEUROSCI.3544-15.2016.
Hakkarainen JJ, Reinisalo M, Ragauskas S, Seppänen A, Kaja S, Kalesnykas G. Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells. Int J Pharm. 2016 Jun 29;511(1):73-78. doi: 10.1016/j.ijpharm.2016.06.135. [Epub ahead of print]
Tuulonen A, Kataja M, Syvänen U, Miettunen S, Uusitalo H. Right services to right patients at right time in right setting in Tays Eye Centre. Acta Ophthalmol. 2016 Jul 16. doi: 10.1111/aos.13168. [Epub ahead of print]
Frederiksen R, Nymark S, Kolesnikov AV, Berry JD, Adler L 4th, Koutalos Y, Kefalov VJ, Cornwall MC. Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods. J Gen Physiol. 2016 Jul;148(1):1-11. doi: 10.1085/jgp.201511538.
Abu Khamidakh AE, Dos Santos FC, Skottman H, Juuti-Uusitalo K, Hyttinen J. Semi-automatic Method for Ca2+ Imaging Data Analysis of Maturing Human Embryonic Stem Cells-Derived Retinal Pigment Epithelium. Ann Biomed Eng. 2016 May 25. [Epub ahead of print].
NCD Risk Factor Collaboration (NCD-RisC) Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants Lancet 2016; 387: 1513–30
Uusitalo H, Egorov E, Kaarniranta K, Astakhov Y, Ropo A. Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials. Clin Ophthalmol. 2016 Mar 15;10:445-54. doi: 10.2147/OPTH.S91402. eCollection 2016.
Huhtala A, Pietilä J, Mäkinen P, Uusitalo H. Femtosecond lasers for laser in situ keratomileusis: a systematic review and meta-analysis. Clinical Ophthalmology 2016:10 393–404.
Laatikainen L, Ojamo M, Rudanko SL, Summanen P, Keinänen-Kiukaanniemi S, Tuomilehto J, Herrala S, Uusitalo H. Improving visual prognosis of the diabetic patients during the past 30 years based on the data of the Finnish Register of Visual Impairment. Acta Ophthalmol. 2016 Feb 29. doi: 10.1111/aos.12952. [Epub ahead of print]
Calejo MT, Ilmarinen T, Jongprasitkul H, Skottman H, Kellomäki M. Honeycomb porous films as permeable scaffold materials for human embryonic stem cell-derived retinal pigment epithelium. J Biomed Mater Res A. 2016 Feb 23. doi: 10.1002/jbm.a.35690. [Epub ahead of print]
Nanni L, Paci M, Caetano Dos Santos FL, Skottman H, Juuti-Uusitalo K, Hyttinen J. Texture Descriptors Ensembles Enable Image-Based Classification of Maturation of Human Stem Cell-Derived Retinal Pigmented Epithelium. PLoS One. 2016 Feb 19;11(2):e0149399. doi: 10.1371/journal.pone.0149399. eCollection 2016.
Väätäinen S, Cederberg H, Roine R, Keinänen-Kiukaanniemi S, Saramies J, Uusitalo H, Tuomilehto J, Martikainen J. Does Future Diabetes Risk Impair Current Quality of Life? A Cross-Sectional Study of Health-Related Quality of Life in Relation to the Finnish Diabetes Risk Score (FINDRISC). PLoS One. 2016 Feb 3;11(2):e0147898. doi: 10.1371/journal.pone.0147898. eCollection 2016.
2015
Mikhailova A, Ilmarinen T, Ratnayake A, Petrovski G, Uusitalo H, Skottman H, Rafat M. Human pluripotent stem cell-derived limbal epithelial stem cells on bioengineered matrices for corneal reconstruction. Exp Eye Res 2015, doi: 10.1016/j.exer.2015.11.021.
Ilmarinen T, Hiidenmaa H, Kööbi P, Nymark S, Sorkio A, Wang JH, Stanzel BV, Thieltges F, Alajuuma P, Oksala O, Kataja M, Uusitalo H, Skottman H. Ultrathin Polyimide Membrane as Cell Carrier for Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium. PLoS One. 2015 Nov 25;10(11):e0143669.
Meyer-Rochow VB, Hakko H, Ojamo M, Uusitalo H, Timonen M. Suicides in visually impaired persons: a nation-wide register-linked study from Finland based on thirty years of data. PLoS ONE 10(10): e0141583. doi:10.1471/journal.pone.0141583.
Uusitalo Hannu ja Ojamo Matti (toim.) Näkövammarekisteri 30 vuotta – pieni juhlakirja Näkökulmia suomalaiseen näkemiseen. Näkövammarekisterin julkaisusarja 1/2015, ISSN 1237-8984.
Juuti-Uusitalo K, Nieminen M, Treumer F, Ampuja M, Kallioniemi A, Klettner A, Skottman H. Effects of Cytokine Activation and Oxidative Stress on the Function of the Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Oct 1;56(11):6265-6274.
Mikhailova A, Jylhä A, Rieck J, Nättinen J, Ilmarinen T, Veréb Z, Aapola U, Beuerman R, Petrovski G, Uusitalo H, Skottman H. Comparative proteomics reveals human pluripotent stem cell-derived limbal epithelial stem cells are similar to native ocular surface epithelial cells. Sci. Rep. 2015; 5:14684.
Lukovic D, Artero Castro A, Delgado AB, Bernal Mde L, Luna Pelaez N, Díez Lloret A, Perez Espejo R, Kamenarova K, Fernández Sánchez L, Cuenca N, Cortón M, Avila Fernandez A, Sorkio A, Skottman H, Ayuso C, Erceg S, Bhattacharya SS. Human iPSC derived disease model of MERTK-associated retinitis pigmentosa. Sci Rep. 2015 Aug 11;5:12910.
Vainio I, Abu Khamidakh A, Paci M, Skottman H, Juuti-Uusitalo K, Hyttinen J, Nymark S. Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells. PLoS One. 2015 Jun 12;10(6):e0128434.
Polinati PP, Ilmarinen T, Trokovic R, Hyötyläinen T, Otonkoski T, Suomalainen A, Skottman H, Tyni T. Patient-Specific Induced Pluripotent Stem Cell-Derived RPE Cells: Understanding the Pathogenesis of Retinopathy in Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency. Invest Ophthalmol Vis Sci. 2015 May 1;56(5):3371-82.
Sorkio A, Porter PJ, Juuti-Uusitalo K, Meenan B, Skottman H, Burke G. Surface modified biodegradable electrospun membranes as a carrier for human embryonic stem cell derived retinal pigment epithelial cells. Tissue Eng Part A. 2015 May 6.
Holappa M, Valjakka J, Vaajanen A. Angiotensin(1-7) and ACE2, “The Hot Spots” of Renin-Angiotensin System, Detected in the Human Aqueous Humor. Open Ophthalmol J. 2015 Mar 31;9:28-32.
Sorkio AE, Vuorimaa-Laukkanen EP, Hakola HM, Liang H, Ujula TA, Valle-Delgado JJ, Österberg M, Yliperttula ML, Skottman H. Biomimetic collagen I and IV double layer Langmuir-Schaefer films as microenvironment for human pluripotent stem cell derived retinal pigment epithelial cells. Biomaterials. 2015 May;51:257-69. doi: 10.1016/j.biomaterials.2015.02.005. Epub 2015 Feb 20.
Vaajanen A, Kalesnykas G, Vapaatalo H, Uusitalo H. The expression of Mas-receptor of the renin-angiotensin system in the human eye. Graefes Arch Clin Exp Ophthalmol. 2015 Feb 14.
Välimäki J, Uusitalo H. Matrix metalloproteinases (MMP-1, MMP-2, MMP-3 and MMP-9, and TIMP-1, TIMP-2 and TIMP-3) and markers for vascularization in functioning and non-functioning bleb capsules of glaucoma drainage implants. Acta Ophtahlmol. 2015 Jan 14.
2014
Tong L, Zhou XY, Jylha A, Aapola U, Liu DN, Koh SK, Tian D, Quah J, Uusitalo H, Beuerman RW, Zhou L. Quantitation of 47 human tear proteins using high resolution multiple reaction monitoring (HR-MRM) based-mass spectrometry. J Proteomics. 2014 Dec 19;115C:36-48.
Pfeiffer N, Traverso CE, Lorenz K, Saarela V, Liinamaa J, Uusitalo H, Astakhov Y, Boiko E, Ropo A. A 6-Month Study Comparing Efficacy, Safety, and Tolerability of the Preservative-free Fixed Combination of Tafluprost 0.0015% and Timolol 0.5% versus Each of Its Individual Preservative-Free Components. Adv Ther. 2014 Dec;31(12):1228-46. Epub 2014 Dec 2.
Ragauskas S, Leinonen H, Puranen J, Rönkkö S, Nymark S, Gurevicius K, Lipponen A, Kontkanen O, Puoliväli J, Tanila H, Kalesnykas G. Early Retinal Function Deficit without Prominent Morphological Changes in the R6/2 Mouse Model of Huntington’s Disease. PLoS One. 2014 Dec 3;9(12):e113317.
Skottman H, Uusitalo H. Silmän kantasoluhoidot. Duodecim 2014;130(19):1991-9.
Käpylä E, Sorkio A, Teymouri S, Lahtonen K, Vuori L, Valden M, Skottman H, Kellomäki M, Juuti-Uusitalo K Ormocomp-Modified Glass Increases Collagen Binding and Promotes the Adherence and Maturation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Langmuir. 2014 Nov 24. [Epub ahead of print]
Helin-Toiviainen M, Rönkkö S, Puustjärvi T, Rekonen P, Ollikainen M, Uusitalo H. Conjunctival matrix metalloproteinases and their inhibitors in glaucoma patients. Acta Ophthalmol. 2014 Oct 13. [Epub ahead of print]
Wang JS, Nymark S, Frederiksen R, Estevez ME, Shen SQ, Corbo JC, Cornwall MC, Kefalov VJ. Chromophore supply rate-limits mammalian photoreceptor dark adaptation. J Neurosci. 2014 Aug 20;34(34):11212-21.
Uusitalo H, Siitonen A, Ojamo M. Glaucoma patients in Finland and thier visual prognosis. Data of the Finnish Register of Visual Impairment during the 30 years. European Glaucoma Society Congress, June 2014, Nice, France. (poster)
Polinati P, Ilmarinen T, Trokovic R, Hyötyläinen T, Otonkoski T, Suomalainen A, Skottman H, Tyni TA. Patient specific induced pluripotent stem cells derived RPE cells: understanding the pathogenesis of retinopathy in LCHAD deficiency. Invest Ophthalmol Vis Sci. 2014 Jun 3. pii: IOVS-14-14007. doi: 10.1167/iovs.14-14007.
Tervonen A, Vainio I, Nymark S, Hyttinen J. Prediction of Passive Drug Permeability Across the Blood-Retinal Barrier. Pharm Res. 2014 Mar 13. [Epub ahead of print]
Mikhailova A, Ilmarinen T, Uusitalo H, Skottman H. Small-molecule induction promotes corneal epithelial cell differentiation from human induced pluripotent stem cells.Stem Cell Reports. 2014 Feb 6;2(2):219-31.
2013
Pietilä J, Huhtala A, Mäkinen P, Salmenhaara K, Uusitalo H. Laser-assisted in situ keratomileusis flap creation with the three-dimensional, transportable Ziemer FEMTO LDV model Z6 I femtosecond laser. Acta Ophthalmol. 2013 Dec 26. doi: 10.1111/aos.12333. [Epub ahead of print]
Pietilä J, Huhtala A, Mäkinen P, Uusitalo H. Flap characteristics, predictability, and safety of the Ziemer FEMTO LDV femtosecond laser with the disposable suction ring for LASIK. Eye (Lond). 2013 Nov 15.
Sorkio A, Hongisto H, Kaarniranta K, Uusitalo H, Juuti-Uusitalo K, Skottman H. Structure and barrier properties of human embryonic stem cell derived retinal pigment epithelial cells are affected by extracellular matrix protein coating. Tissue Eng Part A. 2013 Sep 18.
Välimäki J, Uusitalo H. Immunohistochemical analysis of extracellular matrix bleb capsules of functioning and non-functioning glaucoma drainage implants. Acta Ophthalmol. 2013 Sep 11.
Kauppi T, Kämäräinen JK, Lensu L, Kalesnykiene V, Sorri I, Uusitalo H, Kälviäinen H. Constructing benchmark databases and protocols for medical image analysis: diabetic retinopathy. Comput Math Methods Med. 2013;2013:368514.
Kinnunen K, Heinonen SE, Kalesnykas G, Laidinen S, Uusitalo-Järvinen H, Uusitalo H, Ylä-Herttuala S. LDLR-/-ApoB100/100 mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina. Mol Vis. 2013 Aug 4;19:1723-33.
Juuti-Uusitalo K, Delporte C, Grégoire F, Perret J, Huhtala H, Savolainen V, Nymark S, Hyttinen J, Uusitalo H, Willermain F, Skottman H. Aquaporin expression and function in human pluripotent stem cell-derived retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 2013 May 1; 54(5):3510-9.
Abu Khamidakh AE, Juuti-Uusitalo K, Larsson K, Skottman H, Hyttinen J. Intercellular Ca(2+) wave propagation in human retinal pigment epithelium cells induced by mechanical stimulation. Exp Eye Res 2013, 108:129-139.
2012
Onnela N, Lehtonen L, Koski M, Hyttinen J. In vitro electroretinogram for the study of the functionality of differentiated retinal pigment epithelium cells. Med Biol Eng Comput. 2012 Oct 11 [Epub ahead of print].
Ilmarinen T, Laine J, Juuti-Uusitalo K, Numminen J, Seppänen-Suuronen R, Uusitalo H, Skottman H. Towards a defined, serum- and feeder-free culture of stratified human oral mucosal epithelium for ocular surface reconstruction. Acta Ophthalmol. 2012 Sep 11.
Subrizi A, Hiidenmaa H, Ilmarinen T, Nymark S, Dubruel P, Uusitalo H, Yliperttula M, Urtti A, Skottman H. Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes. Biomaterials 33(32): 8047-54. Epub 2012 Aug 11.
Pietilä J, Huhtala A, Mäkinen P, Uusitalo H. Laser in situ keratomileusis enhancements with the Ziemer FEMTO LDV femtosecond laser following previous LASIK treatments. Graefes Arch Clin Exp Ophthalmol. 2012 Jul 20 [Epub ahead of print]
Pertovaara M, Bootorabi F, Kuuslahti M, Uusitalo H, Pukander J, Helin H, Parkkila S. Carbonic anhydrase autoantibodies and sicca symptoms in primary Sjögren´s syndrome. Clin Exp Rheumatol. 2012 May;30(3):456-457.
Pietilä J, Huhtala A, Mäkinen P, Uusitalo H. LASIK operations with the Ziemer FEMTO LDV femtosecond laser flap creation after previous photorefractive keratometry or laser-assisted sub-epithelial keratomileusis. Acta Ophthalmol. 2012 90 (8):e662-3. Epub 2012 May 25.
Juuti-Uusitalo K, Vaajasaari H, Ryhänen T, Narkilahti S, Suuronen R, Mannermaa E, Kaarniranta K, Skottman H. Efflux protein expression in human stem cell-derived retinal pigment epithelial cells. PLoS One 2012, 7:e30089.
Onnela N, Savolainen V, Juuti-Uusitalo K, Vaajasaari H, Skottman H, Hyttinen J. Electric impedance of human embryonic stem cell-derived retinal pigment epithelium. Med Biol Eng Comput. 2012 50(2): 107-16. Epub 2011, Dec 22.
Pellinen P, Huhtala A, Tolonen A, Lokkila J, Mäenpää J, Uusitalo H. The Cytotoxic Effects of Preserved and Preservative-Free Prostaglandin Analogs on Human Corneal and Conjunctival Epithelium In Vitro and the Distribution of Benzalkonium Chloride Homologs in Ocular Surface Tissues In Vivo. Curr Eye Res, 2012 37(2): 145-154. Epub 2011, Nov 3.
2011
Savolainen V, Juuti-Uusitalo K, Onnela N, Vaajasaari H, Narkilahti S, Suuronen R, Skottman H, Hyttinen J. Impedance spectroscopy in monitoring the maturation of stem cell-derived retinal pigment epithelium. Ann Biomed Eng, 2011, 39:3055-69.
Onnela N, Takeshita H, Kaiho Y, Kojima T, Kobayashi R, Tanaka T, Hyttinen J. Comparison of electrode materials for the use of retinal prosthesis. Biomed Mater Eng, 2011, 21:83-97.
Vaajasaari H, Ilmarinen T, Juuti-Uusitalo K, Rajala K, Onnela N, Narkilahti S, Suuronen R, Hyttinen J, Uusitalo H, Skottman H. Towards defined and xeno-free differentiation of functional human pluripotent stem cell – derived retinal pigment epithelial cells. Mol Vis, 2011, 17:558-575.
Rönkkö S, Kaarniranta K, Kalesnykas G, Uusitalo H. Biocompatibility of different poly(lactide-coglycolide) polymers implanted into the subconjunctival space in rats. Ophthalmic Res, 2011, 46:55-65.
